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- Title
Base‐Promoted Three‐Component Cyclization and Coupling Strategy for the Synthesis of Substituted 3‐Aryl‐5‐thio‐1,3,4‐thiadiazole‐2‐thiones.
- Authors
Guo, Wei; Mei, Weijie; Liu, Gongping; Deng, Ling; Zou, Xiaoying; Zhong, Yumei; Zhuo, Xiaoya; Fan, Xiaolin; Zheng, Lvyin
- Abstract
An effective base‐promoted cyclization and coupling strategy for the construction of substituted 3‐aryl‐5‐thio‐1,3,4‐thiadiazole‐2‐thiones from phenylhydrazines, olefins and CS2 is developed through employing CS2 as a sulfur feedstock. The reaction proceeds under mild reaction conditions in the absence of any external catalysts, transition metals and ligands. The one‐step three‐component procedure also shows the merits of simple operation, using available starting materials, wide substrate scopes, and high atom and step economy. This reaction provides facile access to substituted 3‐aryl‐5‐thio‐1,3,4‐thiadiazole‐2‐thiones, which could be used in the field of drug research.
- Subjects
THIADIAZOLES; RING formation (Chemistry); ALKENES; TRANSITION metals; PHENYLHYDRAZINE; LIGANDS (Chemistry); FEEDSTOCK
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 3, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202100745