We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin.
- Authors
Nosova, Yulia N.; Zenin, Ilia V.; Milaeva, Elena R.; Nazarov, Alexey A.; Maximova, Varvara P.; Zhidkova, Ekaterina M.; Kirsanov, Kirill I.; Lesovaya, Ekaterina A.; Lobas, Anna A.; Gorshkov, Mikhail V.; Kovaleva, Olga N.; Galanski, Markus; Keppler, Bernhard K.
- Abstract
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.
- Subjects
PHYSIOLOGICAL effects of platinum; ANTINEOPLASTIC antibiotics; CELL differentiation; APOPTOSIS; RETINOID X receptors
- Publication
Bioinorganic Chemistry & Applications, 2017, p1
- ISSN
1565-3633
- Publication type
Article
- DOI
10.1155/2017/4736321