We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Use of a Desymmetrized meso Molecule as a Chiral Ligand: Development of Chiral N-Heterocyclic Carbene Ligands for Asymmetric Allylic Arylations with Grignard Reagents.
- Authors
Ando, Shin; Matsunaga, Hirofumi; Ishizuka, Tadao
- Abstract
The desymmetrization of a meso molecule was used for the development of a chiral N-heterocyclic carbene (NHC) ligand. This chiral NHC was then successfully applied to a copper-catalyzed asymmetric allylic arylation with Grignard reagents. The level of stereocontrol was improved to 89 % ee via derivatization studies. The synthesized copper catalyst was effective at the level of 0.05 mol % loading for gram-scale reactions.
- Subjects
MESO compounds; CARBENE synthesis; LIGANDS (Chemistry); HETEROCYCLIC compounds; ARYLATION; GRIGNARD reagents
- Publication
Asian Journal of Organic Chemistry, 2014, Vol 3, Issue 10, p1058
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201402089