Six nitrogenous compounds have been isolated from the coral Echinogorgia sp. collected from South China Sea. Their chemical structures have been identified by MS, NMR as N-2-(1,3-dihydroxyoctadecan-4, 8-dieny)-hexadecamide(1), (E)-N-2-(1,3-dihydroxyoctadecan-4-enly)-hexadecamide (2) ,Uracil(3) ,Thymidine(4) ;2′-deoxyuridine (5) ,Thymine(6). It is the first time to report the six chemical compounds from coral Echinogorgia sp..