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- Title
Maternal Dietary Vitamin D Intake during Pregnancy Is Associated with Allergic Disease Symptoms in Children at 3 Years Old: The Japan Environment and Children's Study.
- Authors
Shimizu, Muneyuki; Kato, Taisuke; Adachi, Yuichi; Wada, Takuya; Murakami, Shokei; Ito, Yasunori; Itazawa, Toshiko; Adachi, Yoko S.; Tsuchida, Akiko; Matsumura, Kenta; Hamazaki, Kei; Inadera, Hidekuni
- Abstract
Introduction: Vitamin D plays an important role in the immune system, and postnatal vitamin D insufficiency is one of the risk factors for the development of allergic disease. However, the effects of women's vitamin D intake during pregnancy on the prevalence of allergic disease in their children remain controversial. Methods: From the Japan Environment and Children's Study, an ongoing nationwide birth cohort study, we obtained information on maternal dietary vitamin D intake determined using a food frequency questionnaire and parent-reported allergic disease symptoms based on the ISAAC questionnaire in children at 3 years of age. Results: From the full dataset of 103,060 pregnancies, we analyzed complete data for 73,309 mother-child pairs. The prevalence of current wheeze, current rhinitis, current rhino-conjunctivitis, current eczema, ever asthma, ever pollinosis, and ever atopic dermatitis in the children was 17.2%, 29.7%, 3.8%, 15.2%, 9.6%, 3.7%, and 11.0%, respectively. The ORs for current rhinitis were significantly lower in the 3rd, 4th, and 5th quintiles than in the 1st quintile after adjustment for various covariates and showed a linear association. The ORs for ever pollinosis were significantly lower in the 2nd, 3rd, and 4th quintiles than in the 1st quintile, showing a U-shaped curve. There was no clear association between mothers' dietary vitamin D intake and symptoms of asthma or atopic dermatitis in their 3-year-old children. Conclusion: Maternal dietary vitamin D intake during pregnancy is associated with the ORs for nasal allergies in children at the age of 3 years. Further studies are warranted to evaluate the appropriate intake dose of vitamin D for pregnant women to prevent the development of nasal allergies in their children.
- Subjects
JAPAN; VITAMIN D; ECZEMA; ALLERGIES; SYMPTOMS; JUVENILE diseases; DISEASE risk factors
- Publication
International Archives of Allergy & Immunology, 2023, Vol 184, Issue 11, p1106
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000531970