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- Title
Cost-effective biomarker for coronary artery disease: time to move on.
- Authors
Roy, Ambuj; Prabhakaran, D.; Sniderman, Allan D.
- Abstract
Serum cholesterol, and in particular LDL cholesterol levels, has been the well-entrenched principle proatherogenic lipoprotein-related marker for the risk of vascular diseases. However, our increasing insights into the pathophysiology of cardiovascular diseases and also data from multiple well-conducted epidemiological studies and clinical trials have distinctly demonstrated the superiority of apoB along with apoB/apoA-1 ratio over conventional measurements of lipids. This superiority of apoB has been proven in population-based studies and also in specific high-risk groups like patients on lipid-lowering therapy, diabetics and South Asians. In this article, we review the current available evidence to demonstrate why apoB and the apoB/ apoA-1 ratio should now be the preferred biomarker of coronary artery disease.
- Subjects
BIOMARKERS; BLOOD cholesterol; CORONARY heart disease prevention; APOLIPOPROTEINS; PATHOLOGICAL physiology; STEROLS
- Publication
Current Science (00113891), 2009, Vol 97, Issue 3, p392
- ISSN
0011-3891
- Publication type
Article