We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recurrence of Phaeochromocytoma and Abdominal Paraganglioma After Initial Surgical Intervention.
- Authors
Johnston, Philip C.; Mullan, Karen R.; Atkinson, A. Brew; Eatock, Fiona C.; Wallace, Helen; Gray, Moyra; Hunter, Steven J.
- Abstract
Background: Clinical and biochemical follow up after surgery for phaeochromocytoma is essential with long term studies demonstrating recurrence frequencies between 6% and 23%. Aim: To examine the characteristics and frequency of tumour recurrence in a regional endocrine referral centre, in patients with surgical resection of phaeochromocytoma (P) and abdominal paraganglioma (AP). Methods: We identified a cohort of 52 consecutive patients who attended our Regional Endocrinology & Diabetes Centre and retrospectively reviewed their clinical, biochemical and radiological data (between 2002 and 2013). After confirmation of early post-operative remission by negative biochemical testing, tumour recurrence was defined by demonstration of catecholamine excess with confirmatory imaging. Results: Phaeochromocytoma was confirmed histologically in all cases (43:P, 9:AP, mean-age:53years). Open adrenalectomy was performed in 20 cases and laparoscopically in 32. Hereditary phaeochromocytoma was confirmed by genetic analysis in 12 (23%) patients. Median follow up time from initial surgery was 47 months, (range: 12 - 296 months), 49 patients had no evidence of tumour recurrence at latest follow-up. Three patients (6%) demonstrated tumour development, one in a patient with VHL which occurred in a contralateral adrenal gland, one sporadic case had local recurrence, and an adrenal tumour occurred in a patient with a SDHB gene mutation who had a previous bladder tumour. After initial surgery, the tumours occurred at 8.6, 12.0 and 17.7 years respectively. Conclusion: In this study tumour development occurred in 6% of patients. Although tumour rates were low, careful and sustained clinical and biochemical follow up is advocated, as new tumour development or recurrence may occur long after the initial surgery is performed.
- Subjects
PHEOCHROMOCYTOMA; PARAGANGLIOMA; ADRENALECTOMY; TUMORS; ABDOMINAL tumors
- Publication
Ulster Medical Journal, 2015, Vol 84, Issue 2, p102
- ISSN
0041-6193
- Publication type
Article