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- Title
Association studies of SEMA6A, SEMA6B, PLXNA2 and PLXNA4 genes in an Irish schizophrenia case-control sample.
- Authors
Kenny, Elaine; Morris, Derek W.; Gilks, William P.; Allott, Emma H.; Donohoe, Gary; Waddington, John L.; Mitchell, Kevin J.; Gill, Michael; Corvin, Aiden P.
- Abstract
Schizophrenia has a substantial genetic component. Finding genetic variants that alter risk may help in identifying pathways that are aetiologically important, both in predicting illness risk and developing treatments. Work by our group and collaborators have identified the Semaphorin 6 and Plexin A gene families as putative susceptibility genes for schizophrenia. Here we report analyses of SEMA6A, PLXNA2, SEMA6B and PLXNA4. SNP maps were generated for all four genes. SNPs located within the gene region were ranked according to their location. Priority was given to SNPs in coding regions, UTR's, splice junctions, promoter regions, evolutionary conserved regions, regions containing clusters of transcription factor binding sites (TFBS) and conserved TFBS. Tag SNPs were chosen using HapMap CEU linkage disequilibrium data. Altogether 74 SNPs were genotyped across the four loci in a sample of 375 schizophrenia cases and 812 controls. Three SNPs at SEMA6A, two SNPs at SEMA6B and three SNPs at PLXNA2 reached nominal levels of significance (p=0.01-0.05) prior to correction for multiple testing. Given the limited power of our association sample and the number of SNPs tested, these findings require independent replication. However, the results may point to a role for abnormal axon guidance and cell migration in schizophrenia pathophysiology.
- Subjects
SCHIZOPHRENIA; GENES; GENETIC polymorphisms; TRANSCRIPTION factors; AXONS; CELL migration
- Publication
Ulster Medical Journal, 2008, Vol 77, Issue 1, p71
- ISSN
0041-6193
- Publication type
Article