We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acute nonlymphocytic leukemia and acute myeloproliferative syndrome following radiation therapy for non-Hodgkin's lymphoma and chronic lymphocytic leukemia: clinical studies.
- Authors
O'Donnell, Joseph F.; Brereton, Harmar D.; Johnson, Ralph E.; Greco, F. Anthony; Gralnick, Harvey R.; O'Donnell, J F; Brereton, H D; Greco, F A; Gralnick, H R; Johnson, R E
- Abstract
Seven cases of acute nonlymphocytic leukemia (ANLL) and one case of a malignant myeloproliferative syndrome have been seen after extensive radiation therapy for non-Hodgkin's lymphoma or chronic lymphocytic leukemia. A myeloproliferative syndrome with abnormalities in granulocytic, erythrocytic, and thrombocytic cell lines was present in all patients and in seven patients preceded ANLL by 2--18 months. The median time to the development of ANLL after primary disease therapy was 61 months (33--98 range). The leukemia was extremely refractory to therapy and median survival after diagnosis of ANLL was two months (range 0--9 months). Leukemia was seen only in those patients who received multiple courses and multiple techniques of radiation therapy.
- Subjects
RADIATION-induced leukemia; LYMPHOCYTIC leukemia; LYMPHOMAS; MULTIPLE tumors; MYELOPROLIFERATIVE neoplasms; RADIATION injuries; SYNDROMES; TIME
- Publication
Cancer (0008543X), 1979, Vol 44, Issue 5, p1930
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197911)44:5<1930::AID-CNCR2820440556>3.0.CO;2-E