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- Title
Pooled analysis of recent studies on magnetic fields and childhood leukaemia.
- Authors
Kheifets, L.; Ahlbom, A.; Crespi, C. M.; Draper, G.; Hagihara, J.; Lowenthal, R. M.; Mezei, G.; Oksuzyan, S.; Schüz, J.; Swanson, J.; Tittarelli, A.; Vinceti, M.; Wunsch Filho, V.; Schüz, J
- Abstract
<bold>Background: </bold>Previous pooled analyses have reported an association between magnetic fields and childhood leukaemia. We present a pooled analysis based on primary data from studies on residential magnetic fields and childhood leukaemia published after 2000.<bold>Methods: </bold>Seven studies with a total of 10,865 cases and 12,853 controls were included. The main analysis focused on 24-h magnetic field measurements or calculated fields in residences.<bold>Results: </bold>In the combined results, risk increased with increase in exposure, but the estimates were imprecise. The odds ratios for exposure categories of 0.1-0.2 μT, 0.2-0.3 μT and ≥0.3 μT, compared with <0.1 μT, were 1.07 (95% CI 0.81-1.41), 1.16 (0.69-1.93) and 1.44 (0.88-2.36), respectively. Without the most influential study from Brazil, the odds ratios increased somewhat. An increasing trend was also suggested by a nonparametric analysis conducted using a generalised additive model.<bold>Conclusions: </bold>Our results are in line with previous pooled analyses showing an association between magnetic fields and childhood leukaemia. Overall, the association is weaker in the most recently conducted studies, but these studies are small and lack methodological improvements needed to resolve the apparent association. We conclude that recent studies on magnetic fields and childhood leukaemia do not alter the previous assessment that magnetic fields are possibly carcinogenic.
- Subjects
BRAZIL; LEUKEMIA treatment; PHYSIOLOGICAL effects of magnetic fields; NONPARAMETRIC signal detection; CARCINOGENICITY; COMPARATIVE studies; ELECTROMAGNETIC fields; RADIATION-induced leukemia; RESEARCH methodology; MEDICAL cooperation; META-analysis; RESEARCH; ENVIRONMENTAL exposure; EVALUATION research; RELATIVE medical risk
- Publication
British Journal of Cancer, 2010, Vol 103, Issue 7, p1128
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605838