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- Title
The CYBA Gene ⁎49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease.
- Authors
Nowak, Tomasz; Niemiec, Paweł; Górczyńska-Kosiorz, Sylwia; Balcerzyk, Anna; Iwanicki, Tomasz; Krauze, Jolanta; Grzeszczak, Wladyslaw; Ochalska-Tyka, Anna; Iwanicka, Joanna; Zak, Iwona
- Abstract
Purpose. Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the ⁎49A>G (rs7195830) polymorphism is associated with CAD. Materials and Methods. CYBA gene ⁎49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method. Results. The frequency of the ⁎49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp., P=0.020), as well as the frequency of the ⁎49G allele (62.2% versus 54.0%, P=0.009). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04–2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08–1.83 for ⁎49G versus ⁎49A). Carrier state of the ⁎49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50–13.20, P=0.002), as well as the ⁎49G allele (OR = 2.25, 95% CI: 1.34–3.77, P=0.001). The ⁎49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease (P=0.015). Conclusion. The CYBA gene ⁎49A>G polymorphism modifies the risk of coronary artery disease.
- Subjects
POLAND; CORONARY disease; CORONARY heart disease risk factors; HYPERTENSION genetics; HYPERTENSION risk factors; LEFT ventricular hypertrophy; ALLELES; CARRIER state (Communicable diseases); CHI-squared test; CONFIDENCE intervals; GENETIC polymorphisms; LIPIDS; NUCLEOTIDES; PROBABILITY theory; RESEARCH funding; SEX distribution; T-test (Statistics); MULTIPLE regression analysis; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio; MANN Whitney U Test; GENOTYPES; DISEASE risk factors; GENETICS
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/1539671