We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Changes in Primary HIV-1 Drug Resistance Due to War Migration from Eastern Europe.
- Authors
Załęski, Andrzej; Lembas, Agnieszka; Dyda, Tomasz; Siwak, Ewa; Osińska, Joanna; Suchacz, Magdalena; Stempkowska-Rejek, Justyna; Strycharz, Marta; Orzechowska, Justyna; Wiercińska-Drapało, Alicja
- Abstract
In recent years, especially as a result of war in Ukraine, enormous movements of migration to Poland from eastern European countries have been reported, including people living with Human Immunodeficiency Virus (HIV). We have conducted multi-center, prospective study, which aimed to establish HIV-1 subtype and assess the presence of primary drug resistance mutations to nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors in antiretroviral treatment naïve patients. The clinical trial recruited 117 individuals during 2 years period (2020–2022). The prevalence of HIV-1 subtype A was statistically significantly more frequent in Ukrainian, and HIV-1 subtype B in Polish patients (p < 0.05). Drug resistance mutations were detected in 44% of all cases and the comparison of presence of mutations in the analyzed groups, as well as in the subgroups of subtype A and B HIV-1 has not revealed any significant differences (p > 0.05), nevertheless Polish patients had multidrug resistance mutations more frequent (p < 0.05). The results from our trial show no increased risk of transmission of multidrug resistant HIV strains in our cohort of Ukrainian migrants. Clinical trials. Gov number NCT04636736; date of registration: November 19, 2020.
- Subjects
RESEARCH; GENETIC mutation; PROTEASE inhibitors; WAR; CONCEPTUAL structures; DESCRIPTIVE statistics; NON-nucleoside reverse transcriptase inhibitors; DRUG resistance in microorganisms; HIV; LONGITUDINAL method; NUCLEOSIDE reverse transcriptase inhibitors
- Publication
Journal of Immigrant & Minority Health, 2024, Vol 26, Issue 1, p15
- ISSN
1557-1912
- Publication type
Article
- DOI
10.1007/s10903-023-01559-1