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- Title
Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review.
- Authors
Torres-Bugarín, Olivia; Macriz Romero, Nicole; Ramos Ibarra, María Luisa; Flores-García, Aurelio; Valdez Aburto, Penélope; Zavala-Cerna, María Guadalupe
- Abstract
Autoimmune diseases (AD) are classified into organ-specific, systemic, and mixed; all forms of AD share a high risk for cancer development. In AD a destructive immune response induced by autoreactive lymphocytes is started and continues with the production of autoantibodies against different targets; furthermore apoptosis failure and loss of balance in oxidative stress as a consequence of local or systemic inflammation are common features seen in AD as well. Micronucleus (MN) assay can be performed in order to evaluate loss of genetic material in a clear, accurate, fast, simple, and minimally invasive test. The MN formation in the cytoplasm of cells that have undergone proliferation is a consequence of DNA fragmentation during mitosis and the appearance of small additional nuclei during interphase. The MN test, widely accepted for in vitro and in vivo genotoxicity research, provides a sensitive marker of genomic damage associated to diverse conditions. In here, we present a review of our work and other published papers concerning genotoxic effect in AD, identified by means of the MN assay, with the aim of proposing this tool as a possible early biomarker for genotoxic damage, which is a consequence of disease progression. Additionally this biomarker could be used for follow-up, to asses genome damage associated to therapies.
- Subjects
AUTOIMMUNE disease diagnosis; AUTOANTIBODIES; AUTOIMMUNE diseases; BEHCET'S disease; BIOMARKERS; CELL nuclei; CHROMOSOMES; DATABASES; DIABETES; GRAVES' disease; MEDICAL information storage &; retrieval systems; MEDLINE; MULTIPLE sclerosis; MUTAGENICITY testing; GENETIC mutation; ONLINE information services; PSORIASIS; RHEUMATOID arthritis; SYSTEMIC lupus erythematosus; SYSTEMIC scleroderma; VITILIGO; SYSTEMATIC reviews
- Publication
BioMed Research International, 2015, Vol 2015, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2015/194031