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- Title
Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia.
- Authors
Jiskoot, Lize C.; Panman, Jessica L.; van Asseldonk, Lauren; Franzen, Sanne; Meeter, Lieke H. H.; Donker Kaat, Laura; van der Ende, Emma L.; Dopper, Elise G. P.; Timman, Reinier; van Minkelen, Rick; van Swieten, John C.; van den Berg, Esther; Papma, Janne M.
- Abstract
Introduction: We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).Methods: Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression.Results: MAPT converters declined on language, attention, executive function, social cognition, and memory, and GRN converters declined on attention and executive function (p < 0.05). Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.Discussion: Using longitudinal neuropsychological assessment, we detected a mutation-specific pattern of cognitive decline, potentially suggesting prognostic value of neuropsychological trajectories in conversion to symptomatic FTD.
- Subjects
FRONTOTEMPORAL dementia; COGNITION disorders; NEUROPSYCHOLOGICAL tests; EXECUTIVE function; SOCIAL perception; MEMORY disorders
- Publication
Journal of Neurology, 2018, Vol 265, Issue 6, p1381
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-018-8850-7