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- Title
Association of In Vitro Fertilization With Childhood Cancer in the United States.
- Authors
Spector, Logan G.; Brown, Morton B.; Wantman, Ethan; Letterie, Gerard S.; Toner, James P.; Doody, Kevin; Ginsburg, Elizabeth; Williams, Melanie; Koch, Lori; Schymura, Maria J.; Luke, Barbara
- Abstract
Importance: In vitro fertilization (IVF) is associated with birth defects and imprinting disorders. Because these conditions are associated with an increased risk of childhood cancer, many of which originate in utero, descriptions of cancers among children conceived via IVF are imperative. Objective: To compare the incidence of childhood cancers among children conceived in vitro with those conceived naturally. Design, Setting, and Participants: A retrospective, population-based cohort study linking cycles reported to the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System from January 1, 2004, to December 31, 2012, that resulted in live births from September 1, 2004, to December 31, 2013, to the birth and cancer registries of 14 states, comprising 66% of United States births and 75% of IVF-conceived births, with follow-up from September 1, 2004, to December 31, 2014. The study included 275 686 children conceived via IVF and a cohort of 2 266 847 children, in which 10 births were randomly selected for each IVF birth. Statistical analysis was performed from April 1, 2017, to October 1, 2018. Exposure: In vitro fertilization. Main Outcomes and Measures: Cancer diagnosed in the first decade of life. Results: A total of 321 cancers were detected among the children conceived via IVF (49.1% girls and 50.9% boys; mean [SD] age, 4.6 [2.5] years for singleton births and 5.9 [2.4] years for multiple births), and a total of 2042 cancers were detected among the children not conceived via IVF (49.2% girls and 50.8% boys; mean [SD] age, 6.1 [2.6] years for singleton births and 4.7 [2.6] years for multiple births). The overall cancer rate (per 1 000 000 person-years) was 251.9 for the IVF group and 192.7 for the non-IVF group (hazard ratio, 1.17; 95% CI, 1.00-1.36). The rate of hepatic tumors was higher among the IVF group than the non-IVF group (hepatic tumor rate: 18.1 vs 5.7; hazard ratio, 2.46; 95% CI, 1.29-4.70); the rates of other cancers did not differ between the 2 groups. There were no associations with specific IVF treatment modalities or indication for IVF. Conclusions and Relevance: This study found a small association of IVF with overall cancers of early childhood, but it did observe an increased rate of embryonal cancers, particularly hepatic tumors, that could not be attributed to IVF rather than to underlying infertility. Continued follow-up for cancer occurrence among children conceived via IVF is warranted. This population-based cohort study compares the incidence of childhood cancers among children conceived in vitro with incidence of childhood cancers among children conceived naturally. Key Points: Question: Is the incidence of childhood cancers among children conceived in vitro different than that among children conceived naturally? Findings: In this population-based cohort study assembled by data linkage, the rate of hepatic tumors was significantly higher among children conceived via IVF than among children conceived naturally (hepatic tumor rate, 18.1 vs 5.7); the rates of other cancers did not differ between the 2 groups. Meaning: An association of conception by IVF with childhood cancer is small and limited to rare tumors; however, continued follow-up for cancer occurrence among children conceived via IVF is warranted.
- Subjects
UNITED States; DIAGNOSIS of tumors in children; LIVER tumors; CONFIDENCE intervals; REPORTING of diseases; FERTILIZATION in vitro; LONGITUDINAL method; EVALUATION of medical care; PREGNANCY; STATISTICS; DATA analysis; TUMORS in children; DISEASE incidence; RETROSPECTIVE studies; ODDS ratio; TUMOR risk factors
- Publication
JAMA Pediatrics, 2019, Vol 173, Issue 6, pe190392
- ISSN
2168-6203
- Publication type
Article
- DOI
10.1001/jamapediatrics.2019.0392