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- Title
Percutaneous biliary stent with intraluminal brachytherapy versus palliative surgery in the management of extrahepatic cholangiocarcinoma.
- Authors
Wang, Yong; Man, Zhongran; Hu, Xiaosi; Zhou, Lei; Jin, Hao; Liu, Huichun; Pang, Qing
- Abstract
Background: To compare the efficacy and outcomes of self-expandable metallic stent combined with catheter-loaded iodine-125 seeds (SEMS-CL-125I) brachytherapy versus conventional palliative surgery (PS) in advanced extrahepatic cholangiocarcinoma (EHCC). Methods: The retrospective analysis consisted of 101 advanced EHCC patients who received SEMS-CL-125I (n = 67) or underwent PS (n = 34). The clinical characteristics, postoperative complications and overall survival (OS) were compared between the two groups. Results: Serum levels of bilirubin, transaminase, and albumin (ALB) were significantly improved at 1 month, 3 months, and 6 months postoperatively in both groups (all P < 0.05). At 1 month after operation, the level of ALB in SEMS-CL-125I group was significantly higher than that in PS group (39.07 ± 3.83 vs. 36.60 ± 5.58 g/L, P = 0.015). No statistically significant difference was found in postoperative overall complications between the two groups (P = 0.052). Length of hospital stay was significantly shorter (P < 0.001), hospital costs were significantly less (P < 0.001), and OS was significantly better (P = 0.029) in SEMS-CL-125I group compared to PS group. Multivariate analysis further identified PS (HR = 2.90, 95% CI 1.71–4.93, P < 0.001) and higher level of carbohydrate antigen 19-9 (HR = 2.67, 95% CI 1.36–3.79, P = 0.002) as independent predictors of worse OS. Conclusion: SEMS-CL-125I significantly improves outcomes compared with PS and could be a safe and effective treatment for advanced EHCC.
- Subjects
CHOLANGIOCARCINOMA; RADIOISOTOPE brachytherapy; TRANSLUMINAL angioplasty; LENGTH of stay in hospitals; CHOLANGIOGRAPHY; HOSPITAL costs; SURGICAL complications
- Publication
International Journal of Clinical Oncology, 2021, Vol 26, Issue 5, p933
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-021-01877-0