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- Title
Pneumonectomy after induction chemoradiotherapy for locally advanced non-small cell lung cancer: should curative intent pulmonary resection be avoided?
- Authors
Yamaguchi, Masafumi; Shimamatsu, Shinichiro; Edagawa, Makoto; Hirai, Fumihiko; Toyozawa, Ryo; Nosaki, Kaname; Seto, Takashi; Takenoyama, Mitsuhiro; Ichinose, Yukito
- Abstract
Purpose: We conducted a retrospective analysis to assess the practicality of pneumonectomy, especially after concurrent induction chemoradiotherapy (i-CRT), for locally advanced non-small cell lung cancer (LA-NSCLC). The operative risks vs. the survival benefit of this procedure for such patients is a subject of controversy.Methods: The subjects of this retrospective study were 71 consecutive LA-NSCLC patients with cStage IIIA-C NSCLC, who underwent i-CRT followed by curative intent pulmonary resection between February, 2001 and March, 2013.Results: Thirty-two patients underwent pneumonectomy (group P) and 39 patients underwent lobectomy (group L). In group P, 17 (54.8%) patients underwent right pneumonectomy. There was no 30-day postoperative mortality in either group and no significant difference in 90-day postoperative mortality between the groups (3.1% vs. 2.6% in groups P and L, respectively). The 5-year overall survival (OS) rate was 58.7% (95% CI: 41.5-75.9%) in group P and 57.3% (95% CI 41.2-73.4%) in group L, without a significant difference between the groups.Conclusion: Our findings suggest that i-CRT followed by pneumonectomy is feasible, with a similar survival benefit to lobectomy. Thus, pneumonectomy after i-CRT should not be avoided as it is a potentially curative intent strategy for carefully selected patients.
- Subjects
PNEUMONECTOMY; NON-small-cell lung carcinoma; CHEMORADIOTHERAPY
- Publication
Surgery Today, 2019, Vol 49, Issue 3, p197
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-018-1751-7