We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reply to Letter to the Editor regarding "Oncological outcomes of squamous cell carcinoma of the cervical esophagus treated with definitive (chemo‐)radiotherapy: a systematic review and meta‐analysis".
- Authors
De Virgilio, Armando; Costantino, Andrea; Festa, Bianca Maria; Mercante, Giuseppe; Franceschini, Davide; Franzese, Ciro; Scorsetti, Marta; Marrari, Andrea; Cavina, Raffaele; Marano, Salvatore; Castoro, Carlo; Spriano, Giuseppe
- Abstract
In a previous study, we performed a meta-analysis of the oncological outcomes of patients suffering from cervical esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Further analysis was performed, and a random effect modeling showed a pooled local–regional failure rate of 41.4% (95% CI 32.2–50.8), and a pooled distant failure rate of 21.6% (95% CI 17.0–26.5). The included studies used a median radiotherapy (RT) dose of 61.2 Gy (95% CI 60.0–62.0, range 56.0–66.0), but we measured a non-significant impact of the RT dose on the pooled overall survival (OS), suggesting that an increased RT dose might not be related to an improved OS (p = 0.23). Further research should be conducted to define predictors and prognostic categories that may select the best treatment option for each patient.
- Subjects
SQUAMOUS cell carcinoma; ESOPHAGUS; RANDOM effects model; RADIOTHERAPY; CANCER patients
- Publication
Journal of Cancer Research & Clinical Oncology, 2023, Vol 149, Issue 3, p1369
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-022-04441-z