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- Title
Synthesis of Amphiphilic Comb-Shape Copolymers Via Ring-Opening Polymerization of a Macromonomer.
- Authors
Zhang, Xiaojin; Zhang, Zhenguo; Su, Xin; Dong, Hui; Zhong, Zhenlin; Zhuo, Renxi
- Abstract
Amphiphilic comb-shape copolymers PCL- co-P(MTC-mPEG16) (where PCL, MTC, and mPEG refer to poly(ε-caprolactone), 2-methyltrimethylene carbonate, and methoxy poly(ethylene glycol), respectively) are synthesized by ring-opening polymerization of ε-caprolactone and cyclic carbonate-terminated PEG macromonomer (MTC-mPEG16) with benzyl alcohol as an initiator and Sn(Oct)2 as a catalyst. Amphiphilic copolymers PCL- co-P(MTC-mPEG16) can form micelles in aqueous solution by self-assembly. The diameters of PCL- co-P(MTC-mPEG16) micelles characterized by dynamic light scattering area few dozens of nanometers with a narrow size distribution and the morphology of the micelles observed through transmission electron microscopy are nanosized spheres. The in vitro drug release of comb-shape copolymer PCL- co-P(MTC-mPEG16) micelles is more stable and sustained than that of linear block copolymers mPEG- b-PCL.
- Subjects
COPOLYMERS; CARBONATES; CAPROLACTONES; MONOMERS; BENZYL alcohol
- Publication
Macromolecular Chemistry & Physics, 2015, Vol 216, Issue 16, p1712
- ISSN
1022-1352
- Publication type
Article
- DOI
10.1002/macp.201500161