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- Title
Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs.
- Authors
Clarke, D. L.; McKune, A.; Thomson, S. R.
- Abstract
<bold>Background: </bold>The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF.<bold>Methods: </bold>In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject.<bold>Results: </bold>After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension.<bold>Conclusions: </bold>Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.
- Subjects
OCTREOTIDE acetate; VASOACTIVE intestinal peptide; HEMORRHAGE; BLOOD flow; HYPERTENSION; GASTRIC mucosa; BLOOD circulation; CARDIOVASCULAR disease diagnosis; CLINICAL trials; COMPARATIVE studies; GASTROINTESTINAL agents; RESEARCH methodology; MEDICAL cooperation; MESENTERIC blood vessels; PATIENT monitoring; PORTAL hypertension; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; PHARMACODYNAMICS
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2003, Vol 17, Issue 10, p1570
- ISSN
1866-6817
- Publication type
journal article
- DOI
10.1007/s00464-002-9274-z