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- Title
The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting.
- Authors
Whiley, David M.; Goire, Namraj; Lahra, Monica M.; Donovan, Basil; Limnios, Athena E.; Nissen, Michael D.; Sloots, Theo P.
- Abstract
From a once easily treatable infection, gonorrhoea has evolved into a challenging disease, which in future may become untreatable in certain circumstances. International spread of extensively drug-resistant gonococci would have severe public health implications. It seems clear that under the current treatment pressure from extended-spectrum cephalosporins, and owing to Neisseria gonorrhoeae's remarkable evolutionary adaptability, further rise of ceftriaxone-resistant strains around the world is inevitable. Simply increasing the doses of extended-spectrum cephalosporins will likely prove ineffective in the long run, and has been a lesson learnt for all single-agent therapies used for gonorrhoea to date. We recommend that dual therapy, especially those consisting of extended-spectrum cephalosporins and azithromycin, be adopted more widely and complemented by strengthening of antimicrobial resistance surveillance. Unless there is urgent action at international and local levels to combat the problem of N. gonorrhoeae antimicrobial resistance, we are in for gloomy times ahead in terms of gonorrhoea disease and control.
- Subjects
DRUG resistance in bacteria; DRUG resistance; NEISSERIA gonorrhoeae; PUBLIC health research; AZITHROMYCIN
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2012, Vol 67, Issue 9, p2059
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dks188