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- Title
Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents.
- Authors
Cotarelo, Manuel; Catalán, Pilar; Sánchez-Carrillo, Carlos; Menasalvas, Ana; Cercenado, Emilia; Tenorio, Antonio; Bouza, Emilio; Cotarelo, M; Catalán, P; Sánchez-Carrillo, C; Menasalvas, A; Cercenado, E; Tenorio, A; Bouza, E
- Abstract
We compare a rapid dilution method for the determination of antiviral susceptibility of herpes simplex virus (HSV) with the plaque reduction assay. A total of 84 HSV clinical isolates were studied by both methods to detect in-vitro resistance to acyclovir and foscarnet. The rapid method showed for the detection of HSV isolates resistant to acyclovir and foscarnet, a sensitivity of 96. 8% and 100% and specificity of 100% and 100%, respectively. This method provides an easy and accurate screening procedure for the susceptibility testing of HSV to antiviral agents.
- Subjects
ACYCLOVIR; ANTIVIRAL agents; HERPES simplex; HERPESVIRUSES; MICROBIAL sensitivity tests; MICROBIOLOGICAL techniques; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1999, Vol 44, Issue 5, p705
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/44.5.705