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- Title
Single-strand break repair and genetic disease.
- Authors
Caldecott, Keith W.
- Abstract
Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many of which are typified by neurological dysfunction and/or increased genetic instability and cancer. Of the different types of DNA damage that arise in cells, single-strand breaks (SSBs) are the most common, arising at a frequency of tens of thousands per cell per day from direct attack by intracellular metabolites and from spontaneous DNA decay. Here, the molecular mechanisms and organization of the DNA-repair pathways that remove SSBs are reviewed and the connection between defects in these pathways and hereditary neurodegenerative disease are discussed.
- Subjects
GENES; GENETIC disorders; NEUROLOGY; CANCER; METABOLITES
- Publication
Nature Reviews Genetics, 2008, Vol 9, Issue 8, p619
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg2380