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- Title
Senescence-Related Truncation and Multimerization of Apolipoprotein A-I in High-Density Lipoprotein With an Elevated Level of Advanced Glycated End Products and Cholesteryl Ester Transfer Activity.
- Authors
Park, Ki-Hoon; Shin, Dong-Gu; Kim, Jae-Ryong; Cho, Kyung-Hyun
- Abstract
To compare the change in lipoprotein metabolism with aging, we analyzed the lipid and protein compositions of individual lipoprotein fractions. Healthy and nonobese elderly participants (elderly group, n = 26) had a serum lipid profile within the normal range, although slightly higher than in young participants (control group, n = 18). However, the elderly group had a twofold higher serum uric acid level and triglyceride (TG):high-density lipoprotein cholesterol ratio. The elderly group had less antioxidant ability and elevated TG content in high-density lipoprotein (HDL) with enhanced cholesteryl ester transfer activity. An elevated level of advanced glycated end products in lipoproteins and fragmentation of apoA-I were present in the elderly group, with detected lower apoA-I level and more multimerized apoA-I in HDL. The protein levels of apoA-I, apoC-III, and serum amyloid A in lipoprotein-deficient serum were increased in the elderly group.
- Subjects
AGING; LIPOPROTEINS; METABOLISM; OLDER people
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2010, Vol 65A, Issue 6, p600
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glq034