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- Title
Association of NRH:Quinone Oxidoreductase 2 Gene Promoter Polymorphism With Higher Gene Expression and Increased Susceptibility to Parkinson's Disease.
- Authors
Wei Wang; Wei-Dong Le; Tianhong Pan; Stringer, Janet L.; Jaiswal, Anil K.
- Abstract
The N-ribosyldihydronicotinamide (NRH):quinone oxidoreductase 2 (NQO2) gene encodes an enzyme that catalyzes activation of quinones. Blood DNA from 80 control individuals and 118 age-matched Parkinson's disease patients were analyzed for NQO2 gene promoter polymorphisms. The results revealed three allelic variants, designated I-29, I-16, and D. These results were confirmed in fibroblast cell lines. In patients with Parkinson's disease, there was a significant increase in the frequency of the D allele, but there was no difference in the frequency of the alleles in familial compared to sporadic Parkinson's disease. The D and 1-16 promoters direct higher NQO2 gene expression that results, in higher enzyme activity. Overexpression of NQO2 in the catecholaminergic neuroblastoma SH-SY5Y cells resulted in increased production of reactive oxygen species when exposed to exogenous dopamine. The results suggest that the association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene.
- Subjects
GENES; GENETIC polymorphisms; GENE expression; PARKINSON'S disease; QUINONE
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2008, Vol 63, Issue 2, p127
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/63.2.127