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- Title
Quantitative analysis of the human T cell palmitome.
- Authors
Morrison, Eliot; Kuropka, Benno; Kliche, Stefanie; Brügger, Britta; Krause, Eberhard; Freund, Christian
- Abstract
Palmitoylation is a reversible post-translational modification used to inducibly compartmentalize proteins in cellular membranes, affecting the function of receptors and intracellular signaling proteins. The identification of protein 'palmitomes' in several cell lines raises the question to what extent this modification is conserved in primary cells. Here we use primary T cells with acyl-biotin exchange and quantitative mass spectrometry to identify a pool of proteins previously unreported as palmitoylated in vivo.
- Subjects
HUMAN T cells; PALMITOYLATION; QUANTITATIVE research; N-ethylmaleimide; HYDROXYLAMINE
- Publication
Scientific Reports, 2015, p11598
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep11598