We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder.
- Authors
Lee, B.-T.; Lee, H.-Y.; Lee, B.-C.; Pae, C.-U.; Yoon, B.-J.; Ryu, S.-G.; Choi, I.-G.; Lee, M.-S.; Ham, B.-J.
- Abstract
Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction. We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele. Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.
- Subjects
ENZYMES; BIOSYNTHESIS; PATHOLOGICAL physiology; AMYGDALOID body; MENTAL depression; MAGNETIC resonance imaging; DEPRESSED persons
- Publication
Genes, Brain & Behavior, 2009, Vol 8, Issue 5, p512
- ISSN
1601-1848
- Publication type
Article
- DOI
10.1111/j.1601-183X.2009.00500.x