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- Title
Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis.
- Authors
Guaschino, Clara; Esposito, Federica; Liberatore, Giuseppe; Colombo, Bruno; Annovazzi, Pietro; D'Amico, Emanuele; Cavalla, Paola; Capello, Elisabetta; Capra, Ruggero; Galimberti, Daniela; Tedeschi, Gioacchino; Grimaldi, Luigi; Leone, Maurizio; D'Alfonso, Sandra; Martinelli, Vittorio; Comi, Giancarlo; Martinelli-Boneschi, Filippo
- Abstract
Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.
- Subjects
FAMILIAL diseases; DISEASE complications; MULTIPLE sclerosis; CLINICAL trials; COMPARATIVE studies; COHORT analysis; PATIENTS
- Publication
Neurological Sciences, 2014, Vol 35, Issue 5, p789
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-014-1650-7