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- Title
室管膜下巨细胞星形细胞瘤的临床及病理特点分析 (附 2 例报告).
- Authors
梁乐; 马康平; 付静; 李云林; 姚晓香
- Abstract
Objective To study the clinicopathology, immunohistochemical characteristic and the differential diagnosis of subependymal giant cell astrocytomas (SEGAs). Methods Two cases of SEGAs were studied by clinicopathological study and immunohistochemistry. Results Two cases of SEGAs occurred during the first two decades of life, arising in the wall of the lateral ventricles and were composed of gemistocytes and sweeping bundles of spindle cells with calcification. Immunohistochemistry showed GFAP, S-100, vimentin, Map-2, Nestin, SOX-2, Caspase-3, Caspase-9 and Bax positive; Neun, CD133, CD34 and Ki-67 negative. Conclusions SEGAs occur commonly in tuberous sclerosis complex, may arise from multipotent neural stem cells, have activation of apoptotic mechanisms and should be differentiated with gemistocytic diffuse astrocytoma, ependymoma, choroid plexus papilloma and subependymoma.
- Publication
Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi, 2017, Vol 14, Issue 3, p186
- ISSN
1672-7770
- Publication type
Article
- DOI
10.3969/j.issn.1672-7770.2017.03.007