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- Title
The interrelation of biomarkers with a predictive role in the evaluation of breast cancer.
- Authors
Rusu-Moldovan, Alina Oana; Zob, Daniela Luminița; Mîrza, Camelia Manuela; Mihu, Dan
- Abstract
Breast cancer clinically represents a heterogeneous disease. Over decades, the integration of prognostic and predictive markers in the treatment decisions has led to a more individualized and optimized therapy. The prognosis describes the risk of disease recurrence and disease-related death after diagnosis without the influence of therapy, and the prediction illustrates the probability of efficacy or response of a specific therapeutic measure. The present study evaluated the clinical significance of Ki-67 index, ER, PGR, cerb-2 and Her2 receptors as prognostic markers and predictors of recurrence in different molecular subtypes of breast cancer. We analyzed the relationship of these receptors with different clinicopathological factors. We have processed samples from 130 patients hospitalized in the Third Surgery Department of the “Prof. Dr. Al. Trestioreanu” Institute of Oncology, Bucharest. The biological samples were taken by breast biopsy punctures or by excision of the tumors, and we analyzed them histopathologically and immunohistochemically. The improved understanding of breast cancer biology and genetics together with the utilization of the classical biomarkers and the identification of new markers or profiles are increasingly defining the clinical decisions that are to be made in order to minimize overtreatment, undertreatment and incorrect treatment.
- Subjects
BUCHAREST (Romania); BREAST cancer; GENETICS of breast cancer; BREAST biopsy; NEEDLE biopsy; DISEASE relapse
- Publication
Oncolog-Hematolog, 2020, Issue 52, p48
- ISSN
2066-8716
- Publication type
Article