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- Title
Ocular melanoma - from theory to medical practice.
- Authors
Zob, Daniela; Stănculeanu, Dana Lucia; Lăzescu, Andreea; Drăgănescu, Mădălina; Branzan, Carmen; Ianculescu, Cristina; Murgoi, Gabriela; Toma, Ştefania; Dascălu, Daniela; Boncescu, Eliza; Laşcu, Bogdan
- Abstract
Ocular melanoma is a distinct entity with an increasing incidence in recent years. The incidence of ocular melanomas in the USA, according to Surveillance, Epidemiology and End Results (SEER), is 0.69/100,000 people per year in men and 0.54/100,000 people per year in women. Ocular melanoma has a particular prognosis and treatment. It represents 5% of all melanomas. Among ocular malignancies, melanomas are the most common. 13% of the deaths due to melanoma are caused by ocular melanoma because of the increased metastatic rate and poor response to treatment. Metastases occur in 31% of patients at 5 years, 45% at 15 years and 50% at 25 years, according to Collaborative Ocular Melanoma Study Group (COMS). Metastases in the liver are the most common - 89% of patients with metastasis. The death rate from metastasis is 80% at 1 year and 92% at 2 years. In recent years, the mutations that occur in ocular melanoma and treatment options have been extensively researched. The results obtained with various systemic therapies are disappointing. In this paper we intend to present prognostic factors and treatment modalities.
- Subjects
OCULAR tumors; MELANOMA treatment; METASTASIS
- Publication
Oncolog-Hematolog, 2017, Issue 39, p54
- ISSN
2066-8716
- Publication type
Abstract