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- Title
Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy?
- Authors
Abdollah, F.; Briganti, A.; Suardi, N.; Gallina, A.; Capitanio, U.; Salonia, A.; Cestari, A.; Guazzoni, G.; Rigatti, P.; Montorsi, F.
- Abstract
The objective was to test the hypothesis that in patients with prostate cancer undergoing radical prostatectomy (RP), diabetic patients are at a higher risk of harboring a high-grade tumor than non-diabetic patients. We examined 2060 consecutive men who underwent RP between 2001 and 2009. Of them, 7.1% had type 2 diabetes mellitus (DM). A high-grade tumor was defined as having a Gleason score 8. Univariable and multivariable logistic regression analyses were used to test the relationship between type 2 DM and high-grade tumor. Mean patient age was 64 years (range: 45-85). Mean total PSA level was 9 ng ml−1 (range: 1-89.5). A significantly higher percentage of diabetic patients had high-grade tumor on biopsy (16.3 vs 7.6%; P=0.001) and on RP specimen (21.1 vs 11.7%; P=0.001) in comparison with non-diabetic patients. In multivariable analyses, DM was an independent predictor of high-grade tumor on biopsy (odds ratio=2.31, P=0.001) and on final pathological specimen (odds ratio=2.22, P=0.002). In patients undergoing RP, those with type 2 DM had a higher risk of harboring a poorly differentiated tumor on final pathological examination.
- Subjects
PROSTATE cancer; PROSTATECTOMY; PEOPLE with diabetes; TUMOR risk factors; BIOPSY
- Publication
Prostate Cancer & Prostatic Diseases, 2011, Vol 14, Issue 1, p74
- ISSN
1365-7852
- Publication type
Article
- DOI
10.1038/pcan.2010.41