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- Title
A rare case of Crigler–Najjar syndrome type 2: A case report and literature review.
- Authors
Rijal, Divas; Rijal, Prabhat; Bohare, Shyam Murti; Chaudhari, Ashish Sanjay; Dhungel, Mandip; Agarwal, Mayank; Bhatta, Pramish; Dhakal, Tulsi Ram; Bishwokarma, Anjali; Kafle, Pooja
- Abstract
Key Clinical Message: Crigler–Najjar syndrome type 2 should be suspected in any young patient presenting with isolated indirect hyperbilirubinemia where all other common etiologies have been excluded. It is a relatively benign condition that responds to phenobarbitone. Crigler–Najjar syndrome (CNS) type 2 is an inborn cause of isolated indirect hyperbilirubinemia characterized by a partial deficiency of the enzyme uridine 5′‐diphosphate‐glucuronosyltransferase (UGT) responsible for bilirubin conjugation. Typically, this condition is diagnosed based on clinical manifestations, supplemented by enzyme analysis if feasible, and exhibits a significant response to phenobarbitone, known for its enzyme‐inducing properties. In this case, we present a young male patient who had experienced recurrent isolated indirect hyperbilirubinemia since early childhood, with negative results in the hemolytic workup. The patient exhibited a UGT1A1 gene defect and demonstrated a highly favorable response to phenobarbitone treatment. The purpose of this report is to raise awareness among physicians about this benign condition and underscore the importance of avoiding unnecessary investigations.
- Subjects
LITERATURE reviews; ENZYME deficiency; SYMPTOMS; SYNDROMES; HYPERBILIRUBINEMIA
- Publication
Clinical Case Reports, 2023, Vol 11, Issue 11, p1
- ISSN
2050-0904
- Publication type
Case Study
- DOI
10.1002/ccr3.8176