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- Title
Multiple endocrine neoplasia-2A-revisited.
- Authors
Jena, Amitabh; Patnayak, Rashmi; Suresh, Vaikkakara; Sachan, Alok; Vijaylaxmi, Bodagala; Manilal, Banoth
- Abstract
Multiple endocrine neoplasia-2A (MEN-2A) is a rare syndrome. MEN-2 is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. MTC is the most consistent feature in all subtypes of MEN-2. In MEN-2A, approximately 70-95% of individuals develop MTC, 50% develop pheochromocytoma, and 15-30% develop hyperparathyroidism. Identification of a germline REarranged in transfection mutation or the identification of the clinical features of MEN-2A in other first-degree relatives is required to make the diagnosis, in those patients with only one or two clinical features. We present the case of a family with MEN-2A syndrome. Here, the patient was first operated for MTC and following further investigation was detected to have pheochromocytoma. In her family history, she had a daughter who was earlier operated for MTC. After 5 years of follow-up, she is doing well. This is an additional case of MEN-2A.
- Subjects
MULTIPLE endocrine neoplasia; ENDOCRINE gland tumors; EPIDEMIOLOGY of cancer; CLINICAL pathology; PHEOCHROMOCYTOMA
- Publication
Clinical Cancer Investigation Journal, 2016, Vol 5, Issue 1, p52
- ISSN
2278-1668
- Publication type
Case Study
- DOI
10.4103/2278-0513.172075