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- Title
Toxicity and T<sub>2</sub>-Weighted Magnetic Resonance Imaging Potentials of Holmium Oxide Nanoparticles.
- Authors
Atabaev, Timur Sh.; Yong Cheol Shin; Su-Jin Song; Dong-Wook Han; Nguyen Hoa Hong
- Abstract
In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG-Ho2O3 NPs. MRI relaxivity measurements revealed that PEG-Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG-Ho2O3 NPs are biocompatible at concentrations less than 16 μg/mL. Overall, the prepared PEG-Ho2O3 NPs have potential applications for T2-weighted MRI imaging.
- Subjects
NANOPARTICLE toxicity; HOLMIUM oxides; MAGNETIC resonance imaging
- Publication
Nanomaterials (2079-4991), 2017, Vol 7, Issue 8, p216
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano7080216