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- Title
[sup 13] C-Methacetin metabolism in patients with cirrhosis: relation to disease severity, haemoglobin content and oxygen supply.
- Authors
Zipprich, A.; Meiss, F.; Steudel, N.; Sziegoleit, U.; Fleig, W. E.; Kleber, G.
- Abstract
Background: Hypoxia may contribute to impairment of liver function and thus interfere with results of liver tests. In patients with cirrhosis, cytochrome P-450 mediated metabolism of substrates is facilitated in the presence of supplemental oxygen. It has not been studied how this relates to liver function and haemoglobin content. Aim: We questioned how oxygen supplementation would influence the hepatic microsomal function as assessed by the [SUP13]C-methacetin breath test in patients with cirrhosis of different severity and different degrees of anaemia. Methods: [SUP13]C/[SUP12]C ratios in exhaled breath assessed by non-dispersive infrared spectrometry were studied in 34 patients with cirrhosis (Child A/B/C 9/17/8) after administration of 75 mg [SUP13]C-methacetin p.o. with and without oxygen inhalation (4 L/min). Results: In patients breathing room air the total amount of [SUP13]C exhaled weakly correlated both with the Child-Pugh score (r = -0.41, P < 0.02) and haemoglobin concentrations (r = 0.46; p = 0.006). Oxygen supplementation increased the total amount of [SUP13]C exhaled by 68 ± 90% (P < 0.001). This effect was similar in Child-Pugh classes A (43 ± 55%), B (83 ± 80%) and C (66 ± 123%) and not related to the Child-Pugh score. Conclusions: Our results suggest that tests of microsomal liver function are independently influenced both by oxygen delivery and the Child-Pugh score.
- Subjects
CIRRHOSIS of the liver; HYPOXEMIA; CYTOCHROME P-450; PHYSIOLOGICAL transport of oxygen; HEMOGLOBINS
- Publication
Alimentary Pharmacology & Therapeutics, 2003, Vol 17, Issue 12, p1559
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2003.01604.x