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- Title
Antibacterial Drug Releasing Materials by Post-Polymerization Surface Modification.
- Authors
Chng, Shuyun; Moloney, Mark G.; Wu, Linda Y. L.
- Abstract
Functional materials are available by the post-polymerization surface modification of diverse polymers in a three-step process mediated, firstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modification with a remotely tethered spiropyran unit, and these materials may be used for the reversible binding and release of Penicillin V. Surface loading densities of up to 0.19mmol/g polymer are achievable, leading to materials with higher loading densities and release behavior relative to unmodified controls, and observable antibacterial biocidal activity.
- Subjects
ANTIBACTERIAL agents; POLYMERIZATION; SURFACE chemistry; CARBENE derivatives; DIAZONIUM compounds
- Publication
Journal of Molecular & Engineering Materials, 2017, Vol 5, Issue 1, p-1
- ISSN
2251-2373
- Publication type
Article
- DOI
10.1142/S2251237317400056