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- Title
PDGF-C is a new protease-activated ligand for the PDGF α-receptor.
- Authors
Li, Xuri; Pontén, Annica; Aase, Karin; Karlsson, Linda; Abramsson, Alexandra; Uutela, Marko; Bäckström, Gudrun; Hellström, Mats; Boström, Hans; Li, Hong; Soriano, Philippe; Betsholtz, Christer; Heldin, Carl-Henrik; Alitalo, Kari; Östman, Arne; Eriksson, Ulf
- Abstract
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF α-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF α-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
- Subjects
PLATELET-derived growth factor; FIBROBLASTS
- Publication
Nature Cell Biology, 2000, Vol 2, Issue 5, p302
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/35010579