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- Title
Drugs in treating paediatric acute kidney injury.
- Authors
Costigan, Caoimhe; Balgobin, Steve; Zappitelli, Michael
- Abstract
Acute kidney injury (AKI) is a complex syndrome which affects a significant proportion of hospitalized children. The breadth and impact of AKI on health outcomes in both adults and children have come to the fore in recent years with increasing awareness encouraging research advancement. Despite this, management strategies for most types of AKI remain heavily reliant on fluid and electrolyte management, hemodynamic optimization, nephrotoxin avoidance and appropriate initiation of kidney replacement therapy. Specific drugs targeting the mechanisms involved in AKI remain elusive. Recent improvement in appreciation of the complexity of AKI pathophysiology has allowed for greater opportunity to consider novel therapeutic agents. A number of drugs specifically targeting AKI are in various stages of development. This review will consider some novel and repurposed agents; interrogate the plausibility of the proposed mechanisms of action, as they relate to what we know about the pathophysiology of AKI; and review the level of existing literature supporting their efficacy. The evidence base, particularly in children, is limited.
- Subjects
THERAPEUTIC use of antioxidants; DRUG efficacy; CYTOKINES; BIOMARKERS; GLOMERULAR filtration rate; ANTI-inflammatory agents; GROWTH factors; INFLAMMATION; INTERSTITIAL nephritis; APOPTOSIS; OXIDATIVE stress; VASODILATORS; INFLAMMATORY mediators; HEMODYNAMICS; PEPTIDE hormones; ACUTE kidney failure; MESENCHYMAL stem cells; CHILDREN; ADOLESCENCE
- Publication
Pediatric Nephrology, 2023, Vol 38, Issue 12, p3923
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-023-05956-4