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- Title
Leap of Faith: Does Serum Luteinizing Hormone Always Accurately Reflect Central Reproductive Neuroendocrine Activity?
- Authors
Moenter, Suzanne M.
- Abstract
The function of the central aspects of the hypothalamic-pituitary-gonadal axis has been assessed in a number of ways including direct measurements of the hypothalamic output and indirect measures using gonadotropin release from the pituitary as a bioassay for reproductive neuroendocrine activity. Here, methods for monitoring these various parameters are briefly reviewed and then examples presented of both concordance and discrepancy between central and peripheral measurements, with a focus on situations in which elevated gonadotropin-releasing hormone neurosecretion is not reflected accurately by pituitary luteinizing hormone release. Implications for the interpretation of gonadotropin data are discussed. © 2015 S. Karger AG, Basel
- Subjects
LUTEINIZING hormone releasing hormone; NEUROSECRETION; BLOOD serum analysis; HYPOTHALAMUS physiology; PITUITARY gland physiology; NEUROENDOCRINOLOGY
- Publication
Neuroendocrinology, 2015, Vol 102, Issue 4, p256
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000438790