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- Title
Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis.
- Authors
Min, Booki; Thornton, Angela; Caucheteux, Stephan M.; Younes, Souheil-Antoine; Oh, Keunhee; Hu-Li, Jane; Paul, William E.
- Abstract
CD25 regulatory T cells (Treg) are a heterogeneous population that exists as CD44 and CD44 cells. Here we report that while both CD44 and CD44 Treg are anergic and express similar levels of Foxp3, CD44 Treg are highly proliferative in vivo and are more potent suppressors in vitro than CD44 Treg. From analysis of the properties of Treg derived from germ-free mice, it was concluded that peptide antigens derived from intestinal microorganisms are not essential for the generation, in vivo proliferation or suppressive activity of Treg. Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg.
- Publication
European Journal of Immunology, 2007, Vol 37, Issue 7, p1916
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200737236