We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Autophagy sustains glutamate and aspartate synthesis in Saccharomyces cerevisiae during nitrogen starvation.
- Authors
Liu, Kuanqing; Sutter, Benjamin M.; Tu, Benjamin P.
- Abstract
Autophagy catabolizes cellular constituents to promote survival during nutrient deprivation. Yet, a metabolic comprehension of this recycling operation, despite its crucial importance, remains incomplete. Here, we uncover a specific metabolic function of autophagy that exquisitely adjusts cellular metabolism according to nitrogen availability in the budding yeast Saccharomyces cerevisiae. Autophagy enables metabolic plasticity to promote glutamate and aspartate synthesis, which empowers nitrogen-starved cells to replenish their nitrogen currency and sustain macromolecule synthesis. Our findings provide critical insights into the metabolic basis by which autophagy recycles cellular components and may also have important implications in understanding the role of autophagy in diseases such as cancer. Autophagy is known to promote cellular survival upon starvation, although how recycled components fit into cellular metabolism has not been well established. Here, the authors show in yeast that autophagy tunes cellular metabolism based on nitrogen availability via glutamate and aspartate synthesis.
- Subjects
SACCHAROMYCES cerevisiae; AUTOPHAGY; ASPARTATES; GLUTAMIC acid; CELL anatomy
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-020-20253-6