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- Title
The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer.
- Authors
Parizadeh, Seyed Mostafa; Jafarzadeh‐Esfehani, Reza; Fazilat‐Panah, Danial; Hassanian, Seyed Mahdi; Shahidsales, Soodabeh; Khazaei, Majid; Parizadeh, Seyed Mohammad Reza; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.; Avan, Amir
- Abstract
Colorectal cancer (CRC) is the third most common cancer and a common cause of cancer‐related mortality globally. In spite of the improvements in the early diagnosis of CRC, approximately one‐third of patients develop metastasis and then have a very poor survival rate. The mesenchymal–epithelial transition factor (c‐MET) is a tyrosine kinase cell surface receptor activated by hepatocyte growth factor (HGF). Activation of c‐MET/HGF signaling pathway regulates a variety of biological processes including cell motility, cell proliferation, angiogenesis, the epithelial‐to‐mesenchymal transition, and the development and progression of cancer cells. Recent studies have suggested that the c‐MET/HGF signaling pathway is involved in the carcinogenesis of CRC. In this review, we summarize the main findings of recent studies investigating the role of c‐MET/HGF signaling pathway in CRC and the potential of the c‐MET/HGF signaling pathways in the diagnosis and treatment of CRC. © 2019 IUBMB Life, 2019
- Subjects
MET receptor; COLORECTAL cancer; CELL receptors; CANCER-related mortality; PROTEIN-tyrosine kinases
- Publication
IUBMB Life, 2019, Vol 71, Issue 7, p802
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.2063