We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EFFECT OF ALENDRONATE-CONTAINING COATINGS ON OSTEOINTEGRATION INTO POROUS TANTALUM IN A CORTICAL BONE MODEL.
- Authors
DUAN, KE; HU, YOUXIN; LONG, KAREN; TOMS, ANDREW; BURT, HELEN M.; OXLAND, THOMAS R.; MASRI, BAS A.; DUNCAN, CLIVE P.; GARBUZ, DONALD S.; WANG, RIZHI
- Abstract
Hip replacement is extensively performed in hips with serious damages. The clinical outcomes of hip implants remain to be improved. Local delivery of bisphosphonates may improve implant fixation by positively affecting local bone modeling. In this study, two alendronate-containing coatings were prepared on porous tantalum by electrolytic deposition. Calcium phosphate coating was deposited and adsorbed with alendronate; the resulting coating had a low drug dose and slow release rate. Solid calcium alendronate coating was also deposited on tantalum; the resulting coating had high drug dose and faster release rate. The effects of the two coatings on new bone formation and implant fixation were studied in the rabbit tibial cortex. Four weeks after implantation, the implants with adsorbed alendronate showed the highest total new bone formation and mechanical fixation, whereas the implants with solid drug coating showed slightly lower fixation and total new bone formation than control bare implants. The improvement by the alendronate-adsorbed calcium phosphate coating provides potentials of enhancing early fixation of porous implants. The solid drug coating warranted further studies to exploit its high drug dose for inhibiting future osteolysis.
- Publication
Nano Life, 2012, Vol 2, Issue 1, p-1
- ISSN
1793-9844
- Publication type
Article
- DOI
10.1142/S1793984411000414