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- Title
In vitro effect of paediatric liquid medicines on deciduous enamel exposed to biofilm.
- Authors
Soares, Daniela Novaes; Antonio, Andréa Gonçalves; Pierro, Viviane Santos da Silva; Iorio, Natalia Lopes Pontes; dos Santos, Kátia Regina Netto; Maia, Lucianne Cople
- Abstract
Objective. This study aimed to assess the in vitro effects of paediatric liquid medicines on deciduous enamel exposed to biofilms. Methods. Fragments ( n = 25) of first primary molars were covered by nail varnish, leaving a 22 mm2 exposure area. Specimens were fixed in polystyrene plates containing BHI broth media. Pooled human saliva was added to form a mature biofilm on fragments over a 10-day period in microaerophilic conditions. Specimens were divided into groups ( n = 5 per group) and treated (50 μL) daily for 1 min over 1 week as follows: G1 = 10% sucrose solution (positive control); G2 = Dimetapp Elixir® (antihistamine); G3 = Claritin® (antihistamine); and G4 = Klaricid® (antibiotic). Five other fragments, without treatment and inoculum represented the blank controls. The covered area for each specimen represented the negative control. Cross-sectional hardness of the enamel was used as a demineralization indicator. Results. All treatment groups showed hardness loss compared to the corresponding negative controls ( p < 0.05). Among the treatment groups, G2 exhibited the greatest demineralization pattern ( p < 0.05) followed by G3, G1 and G4. Conclusion. All medicines caused deciduous enamel demineralization in the presence of biofilm. The greatest hardness loss was observed after treatment with Dimetapp Elixir®.
- Subjects
DENTAL enamel; DECIDUOUS teeth; BIOFILMS; MICROHARDNESS; POLYSTYRENE; SUCROSE; TOOTH demineralization; SALIVA
- Publication
Acta Odontologica Scandinavica, 2013, Vol 71, Issue 5, p1136
- ISSN
0001-6357
- Publication type
Article
- DOI
10.3109/00016357.2012.750013