We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reactive hyperemia correlates with the presence of sepsis and glycocalyx degradation in the intensive care unit: a prospective cohort study.
- Authors
Gomes Malheiro, Luís Filipe; Gaio, Rita; Vaz da Silva, Manuel; Martins, Sandra; Sampaio, Susana; Quelhas-Santos, Janete; Cerqueira, Ana; Sarmento, António; Santos, Lurdes
- Abstract
Objective: To investigate whether reactive hyperemia measured by peripheral arterial tonometry correlates with markers of endothelial dysfunction and may be used to identify sepsis in critical illness. Methods: A prospective study was performed using a cohort of critically ill patients. Endothelial dysfunction was assessed on admission by quantifying reactive hyperemia-peripheral arterial tonometry and plasma levels of endothelin-1, soluble E-selectin, endocan and syndecan-1. Septic patients were compared to patients without evidence of infection. Results: Fifty-eight septic patients were compared to 28 controls. The natural logarithm of reactive hyperemiaperipheral arterial tonometry was negatively correlated with cardiovascular comorbidities, disease severity and plasma levels of soluble E-selectin (p = 0.024) and syndecan-1 (p < 0.001). The natural logarithm of reactive hyperemiaperipheral arterial tonometry was lower in septic patients than in controls (0.53 ± 0.48 versus 0.69 ± 0.42, respectively). When adjusted for age, the multivariable model predicted that each 0.1-unit decrease in natural logarithm of reactive hyperemia-peripheral arterial tonometry increased the odds for infection by 14.6%. m. Conclusion: Reactive hyperemiaperipheral arterial tonometry is closely related to soluble E-selectin and syndecan-1, suggesting an association between endothelial activation, glycocalyx degradation and vascular reactivity. Reactive hyperemia-peripheral arterial tonometry appears to be compromised in critically ill patients, especially those with sepsis.
- Subjects
HYPEREMIA; SEPSIS; GLYCOCALYX
- Publication
Revista Brasileira de Terapia Intensiva, 2020, Vol 32, Issue 3, p363
- ISSN
0103-507X
- Publication type
Article
- DOI
10.5935/0103-507X.20200064