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- Title
CD4<sup>+</sup>CD25<sup>+</sup> T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis.
- Authors
Siqueira-Batista, Rodrigo; Gomes, Andréia Patrícia; Milward Azevedo, Sarah Fumian; Vitorino, Rodrigo Roger; Gomes de Mendonça, Eduardo; Oliveira de Sousa, Flávio; de Paiva Oliveira, Alcione; Ribeiro Cerqueira, Fábio; Oliveira de Paula, Sérgio; de Almeida Oliveira, Maria Goreti
- Abstract
The systemic inflammatory response represents the core pathogenic event of sepsis, underlying clinical manifestations and laboratory findings in patients. Numerous studies have shown that CD4+CD25+ T lymphocytes, also known as regulatory T lymphocytes (Treg), participate in the development of sepsis due to their ability to suppress the immune response. The present article discusses the role of Treg lymphocytes in sepsis based on a specific search strategy (Latin American and Caribbean Health Sciences / Literatura Latino-americana e do Caribe em Ciencias da Saude - LILACS, PubMed, and Scientific Electronic Library Online - SciELO) focusing on two main topics: the participation of Treg cells in inflammation and immunity as well as perspectives in the computational physiological investigation of sepsis.
- Subjects
T cell differentiation; PATHOLOGICAL physiology; SEPSIS; IMMUNOREGULATION; IMMUNE system; IMMUNOLOGY
- Publication
Revista Brasileira de Terapia Intensiva, 2012, Vol 24, Issue 3, p294
- ISSN
0103-507X
- Publication type
Article
- DOI
10.1590/s0103-507x2012000300014