We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Overexpression of the Interferon-Inducible Isoform 4 of NCOA7 Dissects the Entry Route of Enveloped Viruses and Demonstrates that HIV Enters Cells via Fusion at the Plasma Membrane.
- Authors
Herold, Nikolas
- Abstract
The HIV-1 entry-route is a matter of ongoing controversy, and there is evidence for fusion either at the cell surface or from within endosomes. A recent report demonstrated that isoform 4 of nuclear receptor coactivator 7 (NCOA7iso4) interacts with endolysosomal vacuolar-type H+-ATPase (V-ATPase), increasing lytic activity and thereby severely affecting the entry of vesicular stomatitis virus glycoprotein (VSV-G)-mediated, but not HIV-Env-mediated, entry and infection. As basal expression of NCOA7iso4 is low in the absence of type-1 interferons, its overexpression is a novel tool to study viral entry.
- Subjects
CELL membranes; INTERFERONS; GLYCOPROTEINS; VESICULAR stomatitis; LYTIC cycle
- Publication
Viruses (1999-4915), 2019, Vol 11, Issue 2, p121
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v11020121