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- Title
Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.
- Authors
Albarnaz, Jonas D.; Torres, Alice A.; Smith, Geoffrey L.
- Abstract
The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory.
- Subjects
IMMUNOLOGICAL adjuvants; MONKEYPOX virus; VACCINIA; GENETIC engineering; ANTIVIRAL agents; VACCINATION
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 3, p101
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10030101