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- Title
The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients.
- Authors
Friis, Anna M. C.; Gyllensten, Katarina; Aleman, Anna; Ernberg, Ingemar; Åkerlund, Börje
- Abstract
We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with nonoptimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.
- Subjects
HIV-positive persons; INFECTION; ANTIRETROVIRAL agents; DNA; EPSTEIN-Barr virus; LYMPHOCYTES; CD4 antigen; IMMUNOREGULATION; IMMUNE complex diseases
- Publication
Viruses (1999-4915), 2010, Vol 2, Issue 4, p867
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v2040867